Does C-Reactive Protein Predict Recurrent Preeclampsia?

Abstract

Objective. Evaluate association of the inflammatory marker C-reactive protein with recurrent preeclampsia. Methods. Serum samples collected longitudinally in women with previous preeclampsia from the Maternal-Fetal Medicine Units Network trial of aspirin to prevent preeclampsia were assayed for CRP. Results. Of 255 women studied, 50 developed recurrence. Baseline C-reactive protein concentration was similar between women who did and did not recur. After adjusting for confounders, neither elevated baseline C-reactive protein nor its change over gestation was associated with recurrence. Conclusion. In this group of women with previous preeclampsia, neither baseline C-reactive protein concentration nor change in concentration over gestation was associated with recurrent preeclampsia.

• Pregnancy
• Preeclampsia
• C-Reactive protein
• Inflammation
• Acute-phase reaction