Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Abstract

Objective. To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE). Methods. Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). χ² or Fisher's exact test were used to compare genotype frequencies. The control group included 174 pregnant women matched by race to the study group. Results. Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82 ; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (−137, rs187238): p = 0.74 ; IL-18 (−607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23. Conclusion. The analyzed gene polymorphisms are not associated with PE.

• Cytokines
• Inflammatory mediators
• Preeclampsia
• Genetic Polymorphism

ACKNOWLEDGMENTS

We thank the financial support from FAPESP (07/56791-5; 07/57446-0), CNPq, and CAPES.

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.