A Positive Correlation between Hydrogen Peroxide and Soluble TNF-Alpha Receptor 2 Early in Maternal Blood and At Term in Placenta of Pregnant Women with Preeclampsia

Abstract

Objectives. We hypothesized that hydrogen peroxide (H₂O₂) and soluble TNF-α receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia. Methods. Correlation of H₂O₂ and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture. Results. We showed a positive correlation between increased levels of H₂O₂ and sTNF-R2 early at 10–15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H₂O₂ induced the placental synthesis of sTNF-R2. Conclusion. We propose to consider H₂O₂ and sTNF-R2 as potential biomarkers in predicting preeclampsia.

• Hydrogen peroxide
• Maternal blood
• Placenta
• Preeclampsia
• Soluble TNF-R2

ACKNOWLEDGMENT

The authors thank Danielle Beaulieu and Josée Poulin for recruitment of patients, collection of samples, and providing clinical data. This study was supported by funding provided by the Fondation des étoiles (FE), the Fonds de Recherche en Santé du Québec (FRSQ), the Canadian Instituts of Health Research (CIHR), and the Centre de Recherche Clinique (CRC)-Étienne-Lebel du CHUS.

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.