Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia

Abstract

Objectives: To investigate into an association between circulating levels of vascular factors (VF: ACE, eNOS, PlGF and VEGF) and impaired fetal growth measured as a small for gestational age newborn (SGA) in women with gestational hypertension/preeclampsia. Methods: A prospective observational trial in 46 patients in singleton pregnancies. Concentrations of VF were compared between participants who delivered SGA versus non-SGA newborns. Results: only low levels of ACE were associated with significantly increased risk for SGA (for a cut-off value, LR: 1.4–3.6). Conclusions: Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia.

• Angiogenic factors
• fetal growth
• hypertensive pregnancy
• IUGR
• placenta

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

This work was funded by a research grant awarded by Polish Ministry of Science.