Antibodies to Oxidized Low-Density Lipoprotein, Cardiolipin, and Phosphatidyl Serine Fail to Predict the Risk of Preeclampsia

Abstract

Objective: In view of the data that high levels of antibodies to oxidized low-density lipoprotein (LDL), cardiolipin, and phosphatidyl serine are present in plasma of women with established preeclampsia, we studied whether the risk of preeclampsia could be predicted by these antibodies.

Methods: In our prospective trial, blood samples were drawn from 722 healthy nulliparous women at the first prenatal checkup between 10 and 17 gestational weeks. Twenty of them (2.8%) developed established preeclampsia (blood pressure elevation > 140/100 mm Hg and proteinuria 0.3-8.3 g/24 h). As a control group we studied 42 women who remained normotensive during pregnancy and delivery, and postpartum.

Results: The levels of antibodies to oxidized LDL, cardiolipin, or phosphatidyl serine in women later developing preeclampsia did not differ from levels in women who remained normotensive.

Conclusion: We conclude that antibodies to oxidized low-density lipoprotein, cardiolipin, and phosphatidyl serine fail to predict the risk of preeclampsia.

Key Words:

• Antibodies
• Cardiolipin
• LDL
• Preeclampsia
• Serine