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Clinical and Experimental Hypertension Volume 31, 2009 - Issue 8
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Research Article

Effects of Angiotensin II Receptor Blockers on the Relationships Between Ambulatory Blood Pressure and Anti-Hypertensive Effects, Autonomic Function, and Health-Related Quality of Life

Yasuko Okano The Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, Yokohama City, JapanCorrespondence[email protected] [email protected]
,
Kouichi Tamura The Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, Yokohama City, Japan
,
Shinitirou Masuda The Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, Yokohama City, Japan
,
Motoko Ozawa The Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, Yokohama City, Japan
,
Osamu Tochikubo Ubiquitous Preventive Medicine, Yokohama City University Scool of Medicine, Yokohama City, Japan
&
Satoshi Umemura The Department of Medical Science and Cardiorenal Medicine, Yokoham City University Graduate School of Medicine, Yokohama City, Japan
Pages 680-689 | Received 29 Aug 2008, Accepted 10 Oct 2008, Published online: 10 Dec 2009
 
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Abstract

The aim of the present study was to examine the relationships between the anti-hypertensive effects, autonomic function, and health-related quality of life (HRQOL) following treatment of hypertensive subjects with angiotensin receptor blockers (ARBs) in hypertensives. Nineteen patients with hypertension were assigned randomly to daily treatment with ARBs. After 16 weeks of treatment, blood pressure (BP) and 24 h the ratio of low frequency to high frequency component (LF/HF), an index of sympathovagal balance were decreased by ARBs. The HRQOL scores improved during the study. In this study, ARB therapy was associated with an improvement in BP, autonomic function, and HRQOL.

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