Sodium Tungstate and Vanadyl Sulfate Effects on Blood Pressure and Vascular Prostanoids Production in Fructose-Overloaded Rats

Abstract

This study analyzes the effects of sodium tungstate and vanadyl sulphate in the fructose-overloaded rat, a model of metabolic syndrome. Fructose (9 weeks) increased blood pressure, triglycerydemia, glycemia, and reduced release of vasodilator prostaglandins (prostacyclin and prostaglandin E2 ) in the mesenteric vascular bed. Sodium tungstate prevented those alterations; meanwhile vanadyl sulfate only prevented the increase in glycemia. In conclusion, the present experiments showed that sodium tungstate is more effective than vanadyl sulfate for the treatment of experimental metabolic syndrome in rats.

• tungstate
• vanadyl
• fructose
• prostanoids
• triglycerides

ACKNOWLEDGMENTS

This study was supported by grants from the Secretaría de Ciencia y Técnica of the Universidad de Buenos Aires (Code B 106) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), PIP Code 5497/05.

The authors wish to thank to Diana Grinspon, Magalí Fanelli, Florencia Molina and Carlos Videla for their excellent technical assistance.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.