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Clinical and Experimental Hypertension Volume 33, 2011 - Issue 3
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Research Article

Interaction of ACE and CYP11B2 Genes on Blood Pressure Response to Hydrochlorothiazide in Han Chinese Hypertensive Patients

Yun Li Department of Preventive Medicine, North China Coal Medical University, Tangshan, China
,
Yong Zhou Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
,
Peng Yang Department of neurosurgery, Affiliated Hospital of North China Coal Medical University, Tangshan, China
,
Jian Qing Niu Department of Cardiology, Affiliated Kailuan Hospital, North China Coal Medical University, Tangshan, China
,
Ying Wu Department of Preventive Medicine, North China Coal Medical University, Tangshan, China
,
Dan Dan Zhao Department of Preventive Medicine, North China Coal Medical University, Tangshan, China
&
Shou Ling Wu Department of Cardiology, Affiliated Kailuan Hospital, North China Coal Medical University, Tangshan, ChinaCorrespondence[email protected]
 show all
Pages 141-146 | Received 28 Feb 2010, Accepted 28 Apr 2010, Published online: 26 Jan 2011
 
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Abstract

To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene −344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5mg of HCTZ was given daily. After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 − 344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction.

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