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Clinical and Experimental Hypertension Volume 35, 2013 - Issue 6
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Research Article

Effect of Early Diabetes on the Expression of Alpha-1 Adrenergic Receptors in Aorta and Carotid Arteries of Wistar Kyoto and Spontaneously Hypertensive Rats

Jessica Edith- RodriguezSeccion de Posgrado, Instituto Politecnico Nacional, Mexico
,
Aldo Arturo Resendiz-AlborDepartamento de Bioquímica, Instituto Politecnico Nacional, Mexico
,
Ivonne Maciel Arciniega-MartinezDepartamento de Morfologia, Instituto Politecnico Nacional, Mexico
,
Rafael Campos-RodriguezDepartamento de Bioquímica, Instituto Politecnico Nacional, Mexico
,
Enrique HongFarmacobiologia, Centro de Investigacion y de Estudios Avanzados, Mexico
,
Fengyang HuangDepartmento de Farmacologia y Toxicologia, Hospital Infantil del Mexico, Mexico
&
Santiago VillafañaSeccion de Posgrado, Instituto Politecnico Nacional, MexicoCorrespondence[email protected]
 show all
Pages 389-395 | Received 13 Jun 2012, Accepted 03 Oct 2012, Published online: 07 Nov 2012
 
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Abstract

Hypertension and diabetes have been related to noradrenergic system impairment, especially to the response mediated by alpha-1 receptors. The aim of this work was to investigate possible changes in the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of Wistar Kyoto and spontaneously hypertensive rats after 4 weeks of the onset of diabetes. Our results suggest that early diabetes modifies the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of both WKY and SHR strains in a different way.

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