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Clinical and Experimental Hypertension Volume 35, 2013 - Issue 6
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Research Article

An Additional LDL-Lowering Effect of Amlodipine; Not Only an Antihypertensive?

Zekeriya ArslanDepartment of Cardiology, Gelibolu Hospital, Canakkale, Turkey
,
Seyit Ahmet AyDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Murat KaramanDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Mustafa CakarDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, TurkeyCorrespondence[email protected]
,
Turgay CelikDepartment of Cardiology, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Sevket BaltaDepartment of Cardiology, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Muharrem AkhanDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Hakan SarlakDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Erol ArslanDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Seref DemirbasDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Sait DemirkolDepartment of Cardiology, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
,
Fatih BulucuDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
&
Kenan SaglamDepartment of Internal Medicine, Gulhane Medical Academy, School of Medicine, Etlik-Ankara, Turkey
 show all
Pages 449-453 | Received 12 Sep 2012, Accepted 09 Oct 2012, Published online: 30 Nov 2012
 
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Abstract

Hypertension is a modifiable risk factor for cardiovascular diseases and is associated with several metabolic disorders like dyslipidemia. Higher levels of triglyceride and low-density lipoprotein (LDL) are quite strong factors for the development of cardiovascular diseases. In this study, we investigated the effects of valsartan and amlodipine on the lipid profile in patients with newly diagnosed essential hypertension. We observed a beneficial effect of amlodipine on the lipid profile with a significant reduction of LDL compared to valsartan. In the treatment of hypertension, prior knowledge of the plasma cholesterol levels can be important in antihypertensive drug choice.

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