Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Abstract

Our aim was to determine whether angiotensin type 2 receptors (AT₂R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT₂R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT₂R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

• Angiotensin II
• anesthetized rat
• AT₂ receptors
• CGP42112
• carotid pulse pressure
• pressure overload

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

This work was supported by Secretaría de Investigación y Posgrado del Instituto Politécnico Nacional (SIP-IPN); Comisión de Operación y Fomento de Actividades Académicas del IPN (COFAA); Consejo Nacional de Ciencia y Tecnología (CONACYT).