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Clinical and Experimental Hypertension Volume 37, 2015 - Issue 5
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Original Articles

YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels

Zaiwen FanDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
,
Bo LiuDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China, ;Graduate Student Ministry of Education, Hebei North University, Zhangjiakou, China,
,
Shuai ZhangDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China, ;Graduate Student Ministry of Education, Hebei North University, Zhangjiakou, China,
,
Huiguo LiuDepartment of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, and
,
Yang LiInstitute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
,
Dong WangDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
,
Ying LiuDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
,
Jian LiDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
,
Ning WangDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
,
Yi LiuDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China,
&
Bo ZhangDepartment of Respiratory Medicine, General Hospital of PLA Air Force, Beijing, China, Correspondence[email protected]
 show all
Pages 381-387 | Received 10 Jul 2014, Accepted 20 Oct 2014, Published online: 09 Apr 2015
 
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Abstract

To test the hypothesis that chronic hypoxic pulmonary hypertension (CH-PH) is associated with increased survivin and decreased voltage-gated potassium (KV) channels expression in pulmonary arteries, rats were randomized as: normoxia (N); normoxia + YM155, survivin suppressor (NY); hypoxia (H); hypoxia + YM155 (HY). HY group had significantly reduced pulmonary arterial pressure, right ventricular weight and right ventricular hypertrophy compared with H group. Survivin mRNA and protein were detected in pulmonary arteries of rats with CH-PH, but not rats without CH-PH. YM155 downregulated survivin protein and mRNA. KV channel expression and activity were upregulated after YM155 treatment. Survivin may play a role in the pathogenesis of CH-PH.

Declaration of interest

Authors have no conflicts of interest to declare.

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