New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness

Abstract

The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.

• Dipper
• epicardial adipose tissue
• inflammation
• non-dipper
• YKL-40

Acknowledgments

We sincerely thank assistant professor Levent Demirtas for encouragement and support throughout this study.

Declaration of interest

This study was supported by Erzincan University Committee for Scientific Research Projects (EUBAP No: SAG-A-070114-0050). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.