Cilnidipine but not amlodipine suppresses sympathetic activation elicited by isometric exercise in hypertensive patients

Abstract

Pupillometry was used to evaluate the effects of the calcium channel blockers cilnidipine (CL) and amlodipine (AM) on changes in autonomic nervous activity induced by isometric exercise in patients with hypertension. After handgrip exercise, the velocity of miosis increased in both the CL and AM groups. However, the velocity of mydriasis increased in only the AM group. Velocity slopes of miosis and mydriasis were smaller in the CL group than in the AM group. The low-to-high frequency ratio obtained from pulse wave analysis increased in only the AM group. Sympathetic activation elicited by isometric exercise was suppressed more effectively by CL than by AM.

• Hypertension
• miosis
• mydriasis
• pulse wave
• pupillary function
• sympathetic nerve activity

Declaration of interest

The authors report no conflicts of interest, and they alone were responsible for the content and writing of the article. This study was supported by a Grant-in-Aid for Scientific Research (C) (#26460915) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.