Ambulatory blood pressure and blood pressure load responses to low sodium intervention in Han Chinese population

Abstract

We aimed to illustrate ambulatory blood pressure monitoring parameters responses to low sodium intake and their differences between salt-sensitive and non-salt-sensitive individuals. A total of 186 participants were included in this analysis. Twenty-four hour, day-time and night-time blood pressure (BP) and BP load decreased during low sodium intervention, especially in salt-sensitive (SS) group. After multivariable adjustment, 24-h systolic BP, diastolic BP, mean arterial pressure and BP load responses to low sodium intervention of SS individuals were more pronounced than those of non–salt-sensitive individuals. Thus, reducing salt intake is potentially needed for the prevention of hypertension, especially in SS individuals.

Trial registration: ClinicalTrials.gov identifier: NCT00721721.

• Ambulatory blood pressure monitoring
• Chinese population
• dietary intervention
• low sodium
• salt sensitivity

Declaration of interest

This study is funded by the High-Tech Research and Development Program of China (863 Plan) (2012AA02A516) and by a grant 2011BAI09B03 from the Ministry of Science and Technology, China. The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) is supported by research grants (U01HL072507, R01HL087263 and R01HL090682) from the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.