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Free Radical Research Volume 46, 2012 - Issue 6
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Research Article

A novel WD-repeat protein, WDR26, inhibits apoptosis of cardiomyocytes induced by oxidative stress

Yansheng FengDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Chi ZhangDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China;Department of Pathophysiology, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, People's Republic of China
,
Qi LuoDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Xing WeiDepartment of Pathophysiology, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, People's Republic of China
,
Bimei JiangDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Honglin ZhuDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Lingli ZhangDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Lei JiangDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
,
Meidong LiuDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China
&
Xianzhong XiaoDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of ChinaCorrespondence[email protected]
 show all
Pages 777-784 | Received 21 Dec 2011, Accepted 20 Mar 2012, Published online: 10 Apr 2012
 
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Abstract

WD40 repeat proteins have a variety of functions, such as signal transduction, transcription regulation, cell cycle control, autophagy and apoptosis. WDR26 is a novel protein of WD40 repeat proteins and up-regulated during myocardial cells ischemic preconditioning (IPC) but its role in myocardial cell apoptosis induced by oxidative stress and its subcellular localisation are not clear. So we investigated the subcellular localisation of WDR26 and WDR26 expression in rat myocardial ischaemia-reperfusion injury model and H9c2 cells stimulated by H2O2. The results showed that WDR26 can be located at mitochondria and induced by ischaemia-reperfusion injury and H2O2. Then we examined the effects induced by H2O2 in H9c2 cells WDR26 expression. The results showed that WDR26 expression can inhibit apoptosis induced by H2O2. Further, we demonstrated that WDR26 inhibit cytochrome c release from mitochondria. These founding indicate that WDR26 protects myocardial cells against oxidative stress.

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