Abstract
Antioxidants are believed to have great potential for the treatment of diseases that are induced by oxidative stress. However, their pharmaceutical application is severely limited by their poor bioavailability and low biocompatibility. To solve this problem, the antioxidants can be encapsulated or covalently linked with nanomaterials to form nanoantioxidants. In this review, we aim to summarize the use of nanocarriers for antioxidant delivery and discuss their enhancement of antioxidant activity. We also suggest future research directions toward bringing nanoantioxidants into the realm of clinical applications.
Acknowledgment
This project was supported by the National Natural Science Foundation of China (No. 91227122, 21375133, 31300697, 31225012, 31030023 and 31101021), Institute of Chemistry, Chinese Academy of Sciences (CMS-PY-201339, CMS-PY-201302) and National Basic Research Program of China (973 Program: No. 2011CB503900, 2012CB911000, 2011CB910900).
Declaration of interest
The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.