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Pharmaceutical Development and Technology Volume 18, 2013 - Issue 4
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Research Article

Solubility and stability of indomethacin in arginine-assisted solubilization system

Xiaodan QiDepartment of Pharmaceutics, School of Pharmacy, Hebei Medical University, ShiJiaZhuang, P.R. China
,
Jing ZhangDepartment of Pharmaceutics, School of Pharmacy, Hebei Medical University, ShiJiaZhuang, P.R. China
,
Wei WangDepartment of Pharmaceutics, School of Pharmacy, Hebei Medical University, ShiJiaZhuang, P.R. China
&
Deying CaoDepartment of Pharmaceutics, School of Pharmacy, Hebei Medical University, ShiJiaZhuang, P.R. ChinaCorrespondence[email protected]
Pages 852-855 | Received 21 Jan 2011, Accepted 30 May 2011, Published online: 13 Jul 2011
 
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Abstract

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID).It is practically insoluble in water, which precludes its use in aqueous solution formulations. The effect of arginine on the solubility of indomethacin was investigated in this study. The solubility enhancement of indomethacin by the arginine was observed. Aqueous solution formulation and freeze-drying formulation using arginine as hydrotropes were developed and studied for physical and chemical stability. Freeze-drying is considered as a suitable formulation to enhance shelf life of indomethacin.

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