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Abstract
The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.
Declaration of interest: The submitted article carried out at University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar is an original research work. There is no financial support for this work from any source, any person or any organization. This article has neither been published in any journal nor send to any other journal for publication. This article has been carried out by me with due approval of Institutional Ethics Committee, established as per the guidelines of Indian Council of Medical Research, New Delhi. The committee comprises of a retired High Court judge as Chairman, two nos. of Pharmacologists, two nos. of clinicians, one advocate, one social scientist, one ethicist, and one lay person from the community.