Stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solution

Abstract

A thin-layer chromatographic-densitometric method was used to determine the stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solutions at 22°C, 50°C and 90°C. The degradation of ciprofloxacin and norfloxacin followed first order reaction kinetics in presence of metal ions. The extent of this degradation however depended on the type of metal ion and temperature. Product structures of ciprofloxacin (1-cyclopropyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one) and norfloxacin (1-ethyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one) were determined by analysis of UV spectra and using LC-MS method.

Keywords::

• Ciprofloxacin
• norfloxacin
• stability
• metal ions
• TLC

Acknowledgements

Declaration of interest: We thank the State Committee for Scientific Research of Poland for financial support of this work (Project No. (2P05F02527).