Exceptional oral manifestations of amyloid light chain protein (AL) systemic amyloidosis

Abstract

Oral amyloidosis is usually presented in the tongue and is often associated with multiple myeloma. We present three patients with unusual oral manifestations of primary amyloidosis, which to the best of our knowledge have not been previously published. In two cases the oral manifestation was overt at the time of diagnosis and all cases ended in patient mortality. Since these oral manifestations can contribute to the diagnosis of systemic amyloidosis, clinicians should be made aware of them. Future research should assess the significance of oral manifestation as a prognostic indicator.

Keywords:

• Air obstruction
• systemic amyloidosis
• bleeding
• haematoma
• oral
• orange
• macroglossia
• multiple myeloma
• suffocation

Abbreviations
MM	=	multiple myeloma
AL	=	amyloid light chain protein
IG	=	immunoglobulin

Abbreviations
MM	=	multiple myeloma
AL	=	amyloid light chain protein
IG	=	immunoglobulin

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.