Abstract
We report a patient with primary systemic AL amyloidosis who suffered from remarkable bilateral cervical lymphadenopathy. Intensive chemotherapies, including two cycles of high-dose melphalan with autologous peripheral blood stem cell transplantation, were insufficiently effective for both the lymphadenopathy and amyloidogenic IgGλ-type M-protein in serum, but the patient showed complete haematological remission after extensive surgical removal of enlarged lymph nodes that had massive depositions of λ-type immunoglobulin light chain-derived amyloid. Lymphadenectomy may be a possible therapeutic approach with regard to both cosmetic and haematological aspects in primary systemic AL amyloidosis patients with focal lymphadenopathy.
Abbreviations | ||
FLCs | = | free light chains |
HDM/SCT | = | high-dose melphalan with autologous peripheral blood stem cell transplantation |
VAD | = | vincristine, doxorubicin and dexamethasone |
Abbreviations | ||
FLCs | = | free light chains |
HDM/SCT | = | high-dose melphalan with autologous peripheral blood stem cell transplantation |
VAD | = | vincristine, doxorubicin and dexamethasone |
Acknowledgment
This work was supported by a grant from the Intractable Disease Division, the Ministry of Health and Welfare, Amyloidosis Research Committee in Japan.
Declaration of interest:
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.