A solitary mediastinal mass due to localized AL amyloidosis: case report and review of the literature

Abstract

AL amyloidosis presenting as a solitary mediastinal mass is a rare occurrence, with only a few cases reported in the literature. We describe a case of a man presenting with a mediastinal mass diagnosed as amyloidosis, confirmed by mass spectrometry to consist of lambda light chains. Here we review the literature and discuss treatment options for this rare entity.

• AL amyloidosis
• amyloidoma
• localized amyloidosis
• mass spectrometry
• mediastinal mass

Acknowledgements

We gratefully acknowledge our colleagues in the Amyloidosis Center, Clinical Trials Office, and Solomont Center for Cancer and Blood Disorders at Boston University School of Medicine and Boston Medical Center who assisted with the multidisciplinary evaluation and treatment of this patient with amyloidosis.