Cystathionine β-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population

Abstract

Cystathionine β-synthase (CBS) is a key enzyme that plays a critical role in homocysteine metabolism and intracellular redox balance. We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B₁₂ in 817 individuals (397 patients with coronary artery disease and 420 controls). The CBS 844Ins68 polymorphism alone or in combination with MTHFR C677T and CHDH A119C polymorphisms was not significantly associated with any of the biochemical variables studied.

Keywords::

• CBS 844Ins68
• CHDH A119C
• homocysteine
• Indian population
• MTHFR C677T

Acknowledgements

We are thankful to all the participants in the study. The study was funded by the Council of Scientific and Industrial Research (SIP 006) and the Department of Biotechnology, Govt. of India. J.K. is grateful to the University Grants Commission for his fellowship.

Declaration of interest

All the authors declare no conflict of interest. The work has not been published or under consideration for publication anywhere else.