Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women

Abstract

Background: The leptin:adiponectin ratio (L:A ratio) is an independent predictor of carotid intima-media thickness (CIMT).

Objective: To evaluate whether the leptin:high-molecular-weight adiponectin ratio (L:HA ratio) is associated with CIMT in the general population.

Methods: We investigated the relationship between the L:HA ratio and CIMT in 233 Japanese study participants (106 men and 127 women).

Results: After adjustment for confounding factors, CIMT was significantly correlated with the log L:HA ratio (β = 0.11, p = 0.014) in men, whereas no correlation was observed in women (β = 0.01, p = 0.50).

Conclusion: The L:HA ratio is closely correlated with CIMT in men, but not in women.

Keywords::

• Adiponectin
• carotid intima-media thickness
• high-molecular-weight adiponectin

Acknowledgements

We would like to thank Ms Miho Yoshida for her technical assistance. This work was supported by a Grant-in-Aid from the Japan Society for the Promotion of Science (No. 19 500 600) and the Ministry of Education, Culture, Sports, Science and Technology of Japan through the Nagasaki University Global COE program.

Declaration of interest

None of the authors have any conflicts of interests.