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Biomarkers Volume 16, 2011 - Issue 1
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Original Article

Alpha-1-syntrophin protein is differentially expressed in human cancers

Hina F. BhatDepartment of Biotechnology, University of Kashmir, Jammu and Kashmir, India
,
Rafia A. BabaDepartment of Biotechnology, University of Kashmir, Jammu and Kashmir, India
,
Muneesa BashirDepartment of Biotechnology, University of Kashmir, Jammu and Kashmir, India
,
Safder SaeedDepartment of Biotechnology, University of Kashmir, Jammu and Kashmir, India
,
Deeba KirmaniDepartment of Biochemistry, University of Kashmir, Jammu and Kashmir, India
,
Mudassir M. WaniDepartment of Surgery, Government Medical College, SMHS Hospital, Srinagar, India
,
Nisar A. WaniDepartment of Surgery, Government Medical College, SMHS Hospital, Srinagar, India
,
Khursheed A. WaniDepartment of Surgery, Sheri-Kashmir Institute of Medical Sciences, Soura, Jammu and Kashmir, India
&
Firdous A. KhandayDepartment of Biotechnology, University of Kashmir, Jammu and Kashmir, IndiaCorrespondence[email protected]
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Pages 31-36 | Received 26 May 2010, Accepted 07 Sep 2010, Published online: 24 Nov 2010
 
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Abstract

We studied the expression of α1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective controls while a significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples. No significant difference in expression of SNTA1 protein was observed in stomach, lung, colon and rectal cancers. Our results suggest that SNTA1 has a role in carcinogenesis and could possibly be used as a novel diagnostic or prognostic marker in esophageal and breast cancers.

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