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Abstract
A single-nucleotide polymorphism in the MDM2 promoter (SNP309; rs2279744) causes elevated transcription of this major negative regulator of p53 in several cancer types. We investigated MDM2 SNP309 and CDKN1A (p21/Waf1/Cip1) codon 31 (rs1801270) polymorphisms in 86 cases of cutaneous Kaposi’s sarcoma (KS) from African and Caucasian patients, and 210 healthy controls. A significant increase of the MDM2 SNP309 T/G genotype was observed among classic KS cases (odds ratio 2.38, 95% confidence interval 1.0–5.5). Frequencies of CDKN1A codon 31 genotypes were not significantly different between cases and controls. The results suggest that the MDM2 SNP309 G allele may act as a susceptibility gene for the development of classic KS in Caucasian patients.
Acknowledgements
We thank the late Prof. SK Kyalwazi (Mulago Hospital, Kampala, Uganda), Prof. V.A. Ngu (University Centre for Health Sciences, Yaounde, Cameroon) and Prof. G. Giraldo (National Cancer Institute, Fond. Pascale, Napoli, Italy), who provided information and samples regarding the studied patients.
Declaration of interest
This work was supported by grants from the Ministero della Salute (Programma Integrato Oncologia RO4/2007) and from the ICSC-World Laboratory (project MCD-2/7). The authors report no declarations of interest.