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Biomarkers Volume 16, 2011 - Issue 2
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Research Article

Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas

Feng Wan
,
Christel Herold-MendeDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, GermanyCorrespondence[email protected]
,
Benito CamposDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
,
Franz-Simon CentnerDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
,
Christine DictusDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
,
Natalia BeckerDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
,
Frauke DevensDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
,
Carolin MoglerDepartment of General Pathology, University of Heidelberg, INF 220, 69120 Heidelberg, Germany
,
Jörg FelsbergDepartment of Neuropathology, University of Düsseldorf, 40225 Düsseldorf, Germany
,
Niels GrabeInstitute of Medical Biometry and Informatics, Hamamatsu Tissue Imaging and Analysis (TIGA) Center, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
,
Guido ReifenbergerDepartment of Neuropathology, University of Düsseldorf, 40225 Düsseldorf, Germany
,
Peter LichterDivision of Molecular Genetics, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
,
Andreas UnterbergDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
,
Justo Lorenzo Bermejo
&
Rezvan AhmadiDivision of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
 show all
Pages 136-143 | Received 25 May 2010, Accepted 27 Oct 2010, Published online: 17 Feb 2011
 
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Abstract

To study the clinical relevance of undifferentiated tumour cells in astrocytic gliomas we employed a large tumour tissue microarray (n = 283) with corresponding clinical data and analyzed the expression of Nestin and Sox-2, which mark undifferentiated stem- and progenitor cells in the normal brain.

Both markers were expressed abundantly and staining of nestin significantly increased with WHO grade. Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival.

Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis.

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