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Abstract
Objectives: To identify biomarkers for cancer in asbestosis patients.
Methods: SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer.
Results: Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins.
Conclusions: We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.
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Acknowledgements
The authors would like to thank the patients who have participated in our research.
Declaration of interest
This work was supported in part by grants from the National Institute for Occupational Safety and Health (R01-OH04192, R01-OH07590) to PWB-R and the National Institute of Environmental and Health Sciences (2 P01 ES011810) to LSN. Dr. Brandt-Rauf is currently on the editorial board of Biomarkers.