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Biomarkers Volume 16, 2011 - Issue 3
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Research Article

Leptin and adiponectin in obese and non-obese subjects with asthma

Andréa LessardCentre de recherche clinique de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Québec, Canada
,
Julie St-LaurentCentre de recherche clinique de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Québec, Canada
,
Hélène TurcotteCentre de recherche clinique de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Québec, Canada
&
Louis-Philippe BouletCentre de recherche clinique de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Québec, CanadaCorrespondence[email protected]
Pages 271-273 | Received 29 Sep 2010, Accepted 18 Dec 2010, Published online: 20 Jan 2011
 
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Abstract

Objective: To understand the role of leptin and adiponectin in obese asthmatics.

Methods: We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects.

Results: We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11).

Conclusion: Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.

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