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Biomarkers Volume 16, 2011 - Issue 4
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Research Article

Dramatic changes in catestatin are associated with hemodynamics in acute myocardial infarction

Xinyu WangDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
,
Shunlin XuDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
,
Ying LiangDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
,
Dan ZhuDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
,
Lin MiDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
,
Guisong WangDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China
&
Wei GaoDepartment of Cardiology, Peking University Third Hospital, Beijing, China, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China, and The Reference Laboratory of Ministry of Health on Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, ChinaCorrespondence[email protected]
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Pages 372-377 | Received 11 Feb 2011, Accepted 02 Apr 2011, Published online: 05 May 2011
 
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Abstract

Acute myocardial infarction (AMI) is characterized by complex neuroendocrine activation. To investigate catestatin profiles, serial catestatin levels were determined by enzyme-linked immunosorbent assay in the first week after AMI in 50 patients. Catestatin levels reduced at admission and negatively correlated with heart rates; it increased significantly on the third day but remained decreased at 1 week and positively with blood pressure. In a subgroup of 20 patients admitted within 4 h after onset, circulating catestatin correlated inversely with norepinephrine. Catestatin might be involved in the course of AMI and act as a tool in monitoring the progression of AMI.

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