Abstract
Establishing CYFRA 21-1 detection for noninvasive differential diagnosis of urothelial carcinoma (UC) of bladder would help to improve assessment and follow-up of patients, as well as to improve screening of high-risk groups. The study group comprised of 147 subjects including 72 patients with UC of bladder, 75 controls and 17 follow-up cases. The levels of CYFRA 21-1 in serum, urine and urinary cell lysate were estimated by high sensitivity ELISA. Our results indicate that urinary CYFRA 21-1 provides a high value of overall sensitivity for UC of bladder and is also useful even for detection of low grade tumors that might indicate possible earlier detection and treatment administration.
Acknowledgement
The authors would like to thank Indian Council of Medical Research, New Delhi, India, for financial support, Nitika Badjatia for helping in manuscript preparation and Dr. Guresh Kumar, Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India, for statistical analysis.
Declaration of interest
The authors report no conflict of interest.