Catestatin is useful in detecting patients with stage B heart failure

Abstract

Screening patients with stage B heart failure(HF) may be one strategy for reducing human morbidity. To describe catestatin levels in different stages of HF and evaluate the diagnostic utility of catestatin for detecting stage B HF, we included 300 patients. Catestatin, BNP testing and echocardiogram were performed. Our studies showed catestatin decreased gradually from stage A to C. There was significant difference between stage A and B. Cutoff value for detecting stage B HF was 19.73 ng/ml for catestatin with 90% sensitivity and 50.9% specificity. These results may have implications in the new method to detect patients with stage B HF.

Keywords::

• Catestatin
• B-type brain natriuretic peptide (BNP)
• heart failure
• biomarkers

Acknowledgments

We thank Chao-shu Tang for providing guidance and Yiming Zhao and Lin Zeng for data analysis. We thank Min Chen and Xin Wang for English correction.

Declaration of interest

This work was supported by the National Basic Research Program of China from the National Ministry of Science and Technology (973 program,2007CB512107/2007CB512108, to W. Gao) and Seed Fund (80489-01,to D.Zhu)from Peking University Third Hospital. The authors have no financial disclosures.