Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues

Abstract

Objective: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC).

Methods: CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction.

Results: Intratumoral CIP2A mRNA was not associated with patients’ prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival.

Conclusions: Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.

Keywords::

• Cancerous inhibitor of protein phosphatase 2A (CIP2A)
• hepatocellular carcinoma
• mRNA expression
• Prognosis

Acknowledgments

The authors thank all of the patients who participated in this study.

Declaration of interest

This work was supported by grants from the National Natural Science Foundation of China (Nos. 30872489 and 30972916).