Urinary heme oxygenase-1 in children with congenital hydronephrosis due to ureteropelvic junction obstruction

Abstract

Context: Heme oxygenase-1 (HO-1) is implicated to be correlated with renal function in oxidative stress.

Objective: To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).

Methods: A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.

Results: The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.

Conclusion: Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.

Keywords::

• Heme oxygenase-1
• urinary biomarker
• children
• hydronephrosis
• ureteropelvic junction obstruction

Acknowledgments

Statistician, Ms Xiaoping Shang, is thanked for her great contribution to the statistical analysis in this study.

Declaration of interest

This study was supported by “The Youth Innovation Fund of the First Affiliated Hospital of Zhengzhou University” and Special Research Fund for the Doctoral Program of Colleges of Ministry of Education (No.20114101120010).