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Biomarkers Volume 17, 2012 - Issue 6
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Research Article

Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease

Hiroo WadaDepartment of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, JapanCorrespondence[email protected]
,
Shin-ichi HagiwaraHealth Centre, Honda Engineering & Department of Respiratory Medicine, Jichi Medical School, Tochigi, Japan
,
Erika SaitohDepartment of Respiratory Medicine, Saitama Medical University International Medical Centre, Saitama, Japan
,
Ryuji IekiDepartment of Respiratory Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
,
Yorihiro YamamotoSchool of Biosceince and Biotechnology, Tokyo University of Technology, Tokyo, Japan
,
Ian M. AdcockAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
&
Hajime GotoDepartment of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan
 show all
Pages 520-523 | Received 31 Mar 2012, Accepted 07 May 2012, Published online: 30 May 2012
 
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Abstract

Context and objective: Plasma arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD) were investigated.

Methods: Plasma was extracted and free fatty acids (FFAs) were separated using column chromatography and measured by fluorescence. Plasma 20:4 levels and its percentage relative to total FFA levels (%20:4) were measured in COPD (n = 18) and control (n = 20) subjects.

Results and conclusions: FFA levels were lower in COPD compared with normals. However, there was a significant increase in %20:4 levels in COPD patients (GOLD stage I/II 0.9 ± 0.4%; GOLD stage III/IV 1.1 ± 0.1%) compared with control subjects (0.6 ± 0.1, p < 0.05). %20:4 is a potential biomarker for COPD.

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