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Biomarkers Volume 17, 2012 - Issue 6
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Research Article

FDG-PET for detecting local tumor recurrence of ablated liver metastases: a diagnostic meta-analysis

Loukia S. PoulouDepartment of Medical Imaging and Interventional Radiology, General Hospital of Chest Diseases “Sotiria”, Athens, GreeceCorrespondence[email protected]
,
Panayiotis D. ZiakasDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
,
Dimitrios C. ZiogasDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
,
Chrysoula DoxaniDepartment of Biomathematics, School of Medicine, University of Thessaly, Larissa, Greece
,
Vassilia XylaDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
,
George VakrinosDepartment of Medical Imaging and Interventional Radiology, General Hospital of Chest Diseases “Sotiria”, Athens, Greece
,
Michael VoulgarelisDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
&
Loukas ThanosDepartment of Medical Imaging and Interventional Radiology, General Hospital of Chest Diseases “Sotiria”, Athens, Greece
 show all
Pages 532-538 | Received 28 Mar 2012, Accepted 30 May 2012, Published online: 20 Jun 2012
 
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Abstract

Context: Scanty reports have focused on FDG-PET after radiofrequency ablation (RFA), for recurrence of hepatic metastases. Objective: To assess FDG-PET diagnostic accuracy on detection of recurrent hepatic lesions. Methods: After a comprehensive search of PubMed and EMBASE, we performed a patient-based diagnostic meta-analysis of post-RFA FDG-PET. Results: Across nine included articles, independent, random-effects sensitivity and specificity were 0.73(0.50–0.88) and 0.85(0.72–0.93), respectively. A symmetrical SROC curve was produced with no significant heterogeneity. Specificity was optimal for surgical RFA and colorectal origin of metastases. Conclusion: Synthesis of published evidence suggests PET/CT as an appropriate tool for optimizing post-ablation follow-up.

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