Interleukin receptor family member ST2 concentrations in patients following heart transplantation

Abstract

Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT).

Methods: sST2 concentrations were measured in 241 patients following OHT.

Results: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15–3.51; p = 0.01).

Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.

• Biomarkers
• biopsy
• heart transplantation
• prognosis
• rejection

Acknowledgements

The authors wish to thank Critical Diagnostics Inc for ST2 reagent support.