Abstract
Objective: The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer.
Materials and method: Commercially available ELISA was used to determine VEGF and IL-8 levels.
Results: The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS.
Conclusion: VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.
Acknowledgements
We wish to thank No.202 Hospital for providing the pleural effusion samples. We also thank Professor Liang Bin for her assistance with the statistical analyses.