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Biomarkers Volume 20, 2015 - Issue 2
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Review Article

Blood reflects tissue oxidative stress: a systematic review

Nikos V. MargaritelisSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
,
Aristidis S. VeskoukisSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
,
Vassilis PaschalisSchool of Physical Education and Sport Science, University of Thessaly, Trikala, Greece, and ;Department of Health Sciences, European University Cyprus, Nicosia, Cyprus
,
Ioannis S. VrabasSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
,
Konstantina DiplaSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
,
Andreas ZafeiridisSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
,
Antonios KyparosSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece,
&
Michalis G. NikolaidisSchool of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Serres, Greece, Correspondence[email protected]
 show all
Pages 97-108 | Received 27 Nov 2014, Accepted 23 Dec 2014, Published online: 13 Jan 2015
 
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Abstract

We examined whether the levels of oxidative stress biomarkers measured in blood reflect the tissue redox status. Data from studies that measured redox biomarkers in blood, heart, liver, kidney and skeletal muscle were analyzed. In seven out of nine investigated redox biomarkers (malondialdehyde, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, vitamin C and E) there was generally good qualitative and quantitative agreement between the blood and tissues. In contrast, oxidized glutathione and the reduced to oxidized glutathione ratio showed poor agreement between the blood and tissues. This study suggests that most redox biomarkers measured in blood adequately reflect tissue redox status.

Declaration of interest

The authors report no declarations of interest.

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