Serum wnt5a is a predictor for the prognosis of acute on chronic hepatitis B liver failure

Abstract

Objectives: To find a biomarker to predict the prognosis of acute on chronic hepatitis B liver failure (ACHBLF).

Methods: Expression gene profiles in wnt pathway were determined in serum from 63 patients with ACHBLF, 60 patients with chronic hepatitis B (CHB) and 30 healthy controls (HCs).

Results: Serum wnt5a concentration of 1.553 ng/ml showed a poor prognosis with a sensitivity of 69.23% and a specificity of 83.33% in ACHBLF patients.

Conclusions: Serum wnt5a gene expression might be a potential biomarker for predicting the prognosis of ACHBLF.

• acute on chronic hepatitis B liver failure
• prognosis
• sfrp1
• wnt5a

Declaration of interest

This work was supported by grants from Key Project of Chinese Ministry of Science and Technology (2012ZX10002007, 2013ZX10002001), National Natural Science Foundation of China (81171579, 81201287,81371832), and Science and Technology Development Plan of Shandong Province (2012GSF11846).