Urine survivin, E-cadherin and matrix metalloproteinases as novel biomarkers in children with chronic kidney disease

Abstract

Context: Epithelial–mesenchymal transition (EMT) leads to renal fibrosis and chronic kidney disease (CKD).

Objective: The aim of this study was to assess the usefulness of survivin, E-cadherin and metalloproteinases (MMPs) as biomarkers of CKD-related complications.

Material and methods: Survivin, E-cadherin, MMP-2, MMP-9 and TGFbeta1 were assessed by ELISA in 41 children with CKD stages 3 to 5 and in 23 controls.

Results: The serum and urine values of analyzed parameters were significantly elevated in CKD patients versus controls and correlated with each other.

Conclusions: The observed parameter changes indicate apoptosis, tissue remodeling and fibrosis in CKD children. Urine survivin may become a new biomarker of kidney-specific EMT.

• Apoptosis
• epithelial–mesenchymal transition
• fibrosis
• Hsp27
• sFas
• TGFbeta1

Declaration of interest

The authors report no declaration of interest.