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Abstract
Objective: To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC).
Methods: The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed.
Results: UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001).
Conclusions: The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.
Declaration of interest
The authors report no declarations of interest. This work was financially supported by National Natural Science Foundation of China (21475063), Jiangsu Provincial Special Program of Medical Science (BL2013036) and Medicine Leading Talents of Jiangsu Province (LJ201131).