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Biomarkers Volume 20, 2015 - Issue 3
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Research Article

Association between polymorphisms in IL27 gene and renal cell carcinoma

Yan PuDepartment of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China,
,
Peng ChenDepartment of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China,
,
Bin ZhouLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, and
,
Peng ZhangDepartment of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China
,
Yanyun WangLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, and
,
Yaping SongLaboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, and
&
Lin ZhangDepartment of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, P.R. China, ;Laboratory of Molecular Translational Medicine, West China Institute of Women and Children's Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, and Correspondence[email protected]
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Pages 202-205 | Received 12 Mar 2015, Accepted 11 May 2015, Published online: 10 Jul 2015
 
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Abstract

Context: Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis.

Objective: To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk.

Materials and methods: These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95%CI = 1.095–1.700; rs17855750: p = 0.001, OR = 1.768, 95%CI = 1.245–2.511).

Conclusion: The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.

Declaration of interest

No competing financial interests exist.

This work was supported by the National Natural Science Foundation of China (No. 81172440, No. 81172494, No. 81272821 and No. 81202023); the Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan Province (No. 2012SZ0026); and the Science Foundation for The Excellent Youth Scholars of Sichuan University (No. 2011SCU04A16).

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