Advanced oxidation protein products in predicting acute kidney injury following cardiac surgery

Abstract

To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed a prospective cohort study. Thirty-five (22.3%) patients developed AKI, and 32 age- and gender-matched patients without AKI were selected as control. Serum AOPP 1 h after CPB were significantly higher among AKI patients compared with non-AKI patients (81.8 ± 18.6 versus 67.4 ± 12.5 μmol/L, p < 0.001), with an area under the receiver-operating characteristic (ROC) curve of 0.714. An optimal serum AOPP 1 h after CPB cutoff of 69.9 μmol/L had a sensitivity of 74%, specificity of 63% and a positive predictive value of 68% for predicting AKI. These results demonstrated that serum AOPP might be an early biomarker for AKI after CPB.

• Acute kidney injury
• advanced oxidation protein products
• cardiopulmonary bypass
• early diagnosis
• oxidative stress

Acknowledgements

The authors thank our nurses, Si Wu, Wei Xu, Shuo Cao, Shao-yan Lin and Mei Li, for their assistance, and our patients for their participation.

Declaration of Interest

The authors report no declarations of interest.