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Biomarkers Volume 20, 2015 - Issue 5
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Research Article

Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet

Xugang ShiKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, ;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China,
,
Li WangKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, ;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China,
,
Shuli DuSchool of Life Sciences, Northwest University, Xi’an, Shaanxi, China, and
,
Huijuan WangSchool of Life Sciences, Northwest University, Xi’an, Shaanxi, China, and ;National Engineering Research Center for Miniaturized Detection Systems, Xi’an, Shaanxi, China
,
Tian FengNational Engineering Research Center for Miniaturized Detection Systems, Xi’an, Shaanxi, China
,
Tianbo JinKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, ;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, ;School of Life Sciences, Northwest University, Xi’an, Shaanxi, China, and ;National Engineering Research Center for Miniaturized Detection Systems, Xi’an, Shaanxi, China
&
Longli KangKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, ;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China, Correspondence[email protected]
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Pages 275-286 | Received 11 Feb 2015, Accepted 05 Jun 2015, Published online: 31 Jul 2015
 
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Abstract

Little is known about polymorphic distribution of pharmacogenes among ethnicities, including the Deng people. In this study, we recruited 100 unrelated, healthy Deng people and genotyped them with respect to 76 different single-nucleotide polymorphisms by the PharmGKB database. Our results first indicated that the polymorphic distribution of pharmacogenes of the Deng people is most similar to CHD, suggesting that Deng people have a closest genetic relationship with CHD. Our data will enrich the database of pharmacogenomics and provide a theoretical basis for safer drug administration and individualized treatment plans, promoting the development of personalized medicine.

Acknowledgements

The authors would like to thank BioScience Writers for the assistance in the preparation of this article.

Declaration of interest

The authors report no declarations of interest. This work is supported by Natural Science Foundation of Xizang (Tibet) Autonomous Region (20152R-13-11), Major Training Program of Tibet University for Nationalities (No. 13myZP06), Natural Science Foundation of Xizang (Tibet) Autonomous Region (2010) and Major science and technology research projects of Chinese Ministry of Education (No. 211176).

Supplementary material available online

Supplementary Tables S1-S3.

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