ESAM predicts cardiovascular mortality in diabetic hemodialysis patients

Abstract

Aim: To assess endothelial cell selective adhesion molecule (ESAM) as predictor of cardiovascular mortality in diabetic dialysis patients (DDPs).

Methods: ESAM, clinical and laboratory parameters were assessed in 73 DDP. Cardiovascular mortality was recorded in a 2 years’ prospective observational study.

Results: Baseline ESAM was 17.1 (10.05–24.8) ng/ml and was correlated to phosphate (r = −0.42, p = 0.008), parathormone (r = −0.36, p = 0.048), albumin (r = −0.24, p = 0.048). ESAM significantly predicted cardiovascular death in univariate [HR = 1.03, 95% CI (1.006–1.054), p = 0.01] and multivariate [HR = 1.034, 95% CI (1.003–1.066), p = 0.03] Cox analysis. Time to cardiovascular death was shorter for patients with ESAM >12.44 ng/ml, p = 0.0045.

Conclusion: ESAM is an independent predictor of cardiovascular mortality in DDP.

• Adhesion molecule
• atheroscelorsis
• endothelium
• mineral metabolism

Declaration of interest

The authors report no conflicts of interest. This article was financed by CNCSIS grant Capacitati 750/2014. A.R.P. is a fellow of POSDRU grant (grant no. 159/1.5/S/138776) with title: “Model colaborativ institutional pentru translatarea cercetarii stiintifice biomedicale in practica clinica – TRANSCENT”.