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Biomarkers Volume 21, 2016 - Issue 4
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Research Article

XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Aaron J. SpechtSchool of Health Sciences, Purdue University, West Lafayette, IN, USA,
,
Yanfen LinXinhua Hospital, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Department of Child and Adolescent Healthcare, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China,
,
Marc WeisskopfHarvard School of Public Health, Boston, MA, USA, and
,
Chonghuai YanXinhua Hospital, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Department of Child and Adolescent Healthcare, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China,
,
Howard HuDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
,
Jian XuXinhua Hospital, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Department of Child and Adolescent Healthcare, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Correspondence[email protected]
&
Linda H. NieSchool of Health Sciences, Purdue University, West Lafayette, IN, USA, Correspondence[email protected]
 show all
Pages 347-352 | Received 12 Sep 2015, Accepted 02 Jan 2016, Published online: 09 Feb 2016
 
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Abstract

Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects’ bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.

Declaration of interest

This work was supported by the National Institute for Occupational Safety and Health (NIOSH) R21 grant 1R21OH010044, National Natural Science Foundation of China (81373016, 30901205), National Basic Research Program of China (“973” Program, 2012CB525001), Shanghai Science and Technology Committee [124119a1400], Purdue Ross Fellowship and Purdue US-China visiting scholar network travel grant program. The authors report no declarations of interest.

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