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Medical Mycology Volume 50, 2012 - Issue 4
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Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis

Bettina Schulz *Charité–Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, GermanyCorrespondence[email protected]
,
Mathias Knobloch *Charité–Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany
,
Gary P. MoranMicrobiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Dublin, Ireland
,
Kai Weber *Charité–Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany
&
Markus Ruhnke *Charité–Universitätsmedizin Berlin, Charit Campus Mitte, Medical Department, Division of Oncology and Haematology, Berlin, Germany
Pages 421-426 | Received 15 May 2011, Accepted 26 Jul 2011, Published online: 22 Sep 2011
 

Abstract

The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.

Acknowledgements

We thank Dr K. Tintelnot for providing C. dubliniensis isolates RKI 01-0170-01, RKI 01-0265 and RKI 01-0268-02 and C. Radecke for great technical assistance.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This paper was first published online on Early Online on 22 September 2011.

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