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Original Articles

Efficacy of porcine placental extract on climacteric symptoms in peri- and postmenopausal women

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Pages 28-35 | Received 06 Feb 2012, Accepted 19 May 2012, Published online: 24 Aug 2012
 

ABSTRACT

Objectives Injections of human placental extract have long been used to treat menopausal symptoms. Recently, porcine placental extract (PPE), an oral supplement, has been developed for this purpose. The aim of this study was to assess whether PPE has an impact on climacteric symptoms in perimenopausal and postmenopausal women.

Methods Seventy-six women with climacteric symptoms were enrolled into this open-label, randomized, controlled study. The control group (n = 38) underwent 24 weeks of open treatment with Toki-shakuyaku-san (TJ23), an oral herbal remedy used to alleviate climacteric symptoms. The PPE group (n = 38) received three capsules of PPE/day orally for the initial 12 weeks and six capsules/day for the next 12 weeks. Climacteric symptoms were evaluated in both groups using the Simplified Menopausal Index (SMI) score, Zung's Self-Rating Depression Scale (ZSDS) and the Spielberger State-Trait Anxiety Inventory (STAI) before commencing treatment, after 12 weeks of treatment and on completion of treatment.

Results Treatment with PPE was significantly (p < 0.01) more effective in reducing the SMI, ZSDS and STAI measures at 12 and 24 weeks than TJ23 treatment alone. Treatment with PPE was also significantly effective (p < 0.01) in reducing the subscale scores of the SMI for items such as hot flushes, insomnia, irritability, depression, fatigue and joint pain. PPE treatment had no significant adverse effects.

Conclusion Oral PPE treatment is another possible option for treating perimenopausal and postmenopausal women with climacteric symptoms.

ACKNOWLEDGEMENT

The authors thank Mr Taiichi Kaku (Japan Bio Products Co., Ltd., Tokyo, Japan) for providing PPE (‘JBP Porcine 100’).

Conflict of interest The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

Source of funding This work was partially supported and funded by the NPO Science Research Center for Alternative Medicine, Kanazawa, Ishikawa, Japan.

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